Drug Discovery
Given the pressure on pharmaceutical companies to maintain strong pipelines of novel therapeutic agents and the high cost of failure in drug development, it is crucial that researchers have tools that provide high-quality information efficiently and cost effectively. This has led to the emergence of high-content screening assays, multiplex-functional assays, and pre-clinical toxicology assessments to understand drug candidates earlier in the discovery and development process.
Guava Technologies has streamlined and simplified cell-based assays through an integrated approach of instrument and assay-specific reagents and software. The ability to quickly and accurately perform common cell-based assays whenever and wherever you want enables you to make accurate decisions more quickly and to maximize the productivity of your laboratory.
Guava Systems have proven value throughout the drug discovery process, including:
Target identification, where new disease targets are identified in cell lines by monitoring for gene or protein expression as well as transfection efficiency at the single cell level. This can be done with any Guava System.
Target validation, where the function of new disease targets is confirmed by performing mechanism of action studies. Guava Technologies offers a variety of functional assays useful for this purpose.
Assay development, where cell line and assay conditions are optimized prior to screening studies to ensure optimal assay performance. The Guava EasyCyte Plus, Guava PCA-96, and Guava EasyCyte Mini Systems, with built-in 96-well plate and tube sample inputs, are ideal for this purpose.
High throughput screening, where cells are profiled prior to screens for cell health indicators, such as cell counts and viability, apoptosis, or cell cycle. Routine quality control of cells will ensure accurate assay results, ensuring that you do not miss viable hits.
Secondary screening, where the convenience of the built-in 96-well plate and tube sample input of the Guava EasyCyte Plus, EasyCyte Mini, and PCA-96 Systems give you the ability to perform confirmatory screens and develop EC50 values for your primary hits quickly and easily.
Early safety testing, where the potential toxicity of compounds is assessed against target cells. The Guava ViaCount® Assay and Cell Toxicity and Apoptosis Assays are ideal for this purpose.
Lead optimization, where in depth mechanism of action studies are performed for dose response profiles, time course studies, and specificity. This can be accomplished with most Guava Systems.
Bioprocessing, where biopharma products are produced via cell culture systems; Guava Systems in conjunction with Guava Assays provide ideal solutions for performing cell line characterization and media optimization for bioreactors.
Product quality control, where the quality of your biopharmaceutical product is monitored using target cells to test for a variety of functional responses, such as cell cycle, apoptosis, cell counts and viability, and cytotoxicity. Guava Systems and Assays provide ideal solutions for this purpose.
Clinical trials, where the ease of use, excellent intra- and inter-lab CVs, and broard choice of optimized, functional assays has made Guava Systems a method of choice for monitoring patient samples.
For more information about how a Guava System can support your drug discovery efforts, please visit the following links:
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